Abstract: OBJECTIVE To synthesize melitracen hydrochloride.METHODS The target compound was prepared from o-benzoylbenzoic acid as a starting material via seven steps including reduction, esterification, methylation, cyclazition, oxidation condensation, anhydration and saltlization.RESULTS The structure of the compounds was confirmed by IR, NMR and MS．CONCLUSION Some improvements for the synthesis of melitracen hydrochloride were made and the synthesis route was feasible.