微波技术在药物中间体合成中的应用

Study on application of microwave irradiation in intermediate for drug synthetic reactions

摘要: 目的:运用微波技术进行药物中间体合成。方法:对硝基还原反应、缩合反应、环合反应采用微波催化的方法进行。结果:合成五个药物中间体,反应时间均大大缩短。结论:该方法具有操作简单,反应时间短等优点,有一定实用意义

Abstract: OBJECTIVE: To synthesize the intermediates for drugs by microwave irradiation. METHOD: Reduction reaction, condensation reaction and cyclization reaction were studied by microwave irradiation. RESULTS: Five intermediates were synthesized and time was shor