Abstract: OBJECTIVE To study the common cause, symptoms, treatment and preventive measures of antipsychotic poisoning. METHODS A retrospective investigation method was used to study the 91 patients with antipsychotic poisoning. These patients were admitted to our hospital from January 2000 to December 2009 in clinical. RESULTS The common causes of antipsychotic poisoning were: suicide(55 cases, accounting for 60.44%), inappropriate medication(21 cases, accounting for 23.08%), and accidentally intaking medicine(15 pediatric cases, accounting for 16.48%). The main clinical manifestations included vomiting, unconsciousness, hypotension, extrapyramidal system response and low body temperature, and so on. Treatment measures included gastric lavage, inducing vomiting, catharsis, fluid infusion, diuretic, maintaining blood pressure, sedation, stimulating respiratory center and other symptomatic treatment. There were 64(accounting for 70.33%) patients who were cured, and 27(29.67%) patients improved. CONCLUSION Suicide, inappropriate medication and accidentally intaking medicine are the main reasons for antipsychotic poisoning. Central nervous system disorders and cardiovascular abnormalities are the main clinical manifestations. The therapeutic measures include preventing the absorption, promoting excretion and symptomatic treatment. The preventive measures include strengthening psychological counseling, improving awareness of mental illness and keeping drugs properly.