帕唑帕尼盐酸盐的合成

Synthesis of Pazopanib Hydrochloride

摘要: 目的合成帕唑帕尼盐酸盐并改进合成工艺。方法以3-甲基-6-硝基-1H-吲唑为起始原料，经N-甲基化、还原、亲核取代、成盐等反应制得帕唑帕尼盐酸盐。结果所得产物经核磁共振氢谱、质谱、红外等确证其结构。结论该工艺原料易得，方法简便，适合工业化生产。

Abstract: OBJECTIVE To synthesis pazopanib hydrochloride and optimize the process. METHODS Pazopanib hydrochloride was synthesized from 3-methyl-6-nitro-1H-indazole via N-methylation, reduction, nucleophilic substitution and salification. RESULTS Chemical structure of pazopanib hydrochloride was confirmed by 1H-NMR, MS and IR. CONCLUSION The method is suitable for industry.