Abstract: OBJECTIVE To discuss the relativity between material properties and pelletization by the process of extrusion-spheronization. METHODS Make a summary of both national and overseas papers about the suitability of the wet mass used to produce pellets by extrusion-spheronization. This paper is to determine the relevance between the property of wet powder masses (such as the fluid saturation and mobility, the solubility and the ability of holding water of drugs and accessories, the rheological properties) and pelletization. RESULTS Although many properties are relative to the process of extrusion-spheronization, none of them can predict producing qualified pellet. CONCLUSION This paper gives consultation to the further research and exploitation of the material fit for the process of extrusion-spheronization.