醋酸棉酚宫内给药装置在小鼠体内药动学研究

Evaluation of the Release Rate of Gossypol Acetate from a Gossypol-Loaded Intrauterine Device in Mice

摘要: 目的探索醋酸棉酚宫内给药装置在小鼠体内的药动学特征。方法将醋酸棉酚宫内给药装置放入小鼠子宫内，用HPLC测定血浆中药物浓度。结果醋酸棉酚宫内给药装置放入小鼠子宫中，体内血药浓度在48 h达到高峰(0.30 μg·L^-1)，随后呈现恒速释放的特征。结论醋酸棉酚宫内给药装置在小鼠体内达峰时间迅速，并能长时间维持稳定的药物释放，有望用于子宫腺肌病的治疗。

Abstract: OBJECTIVE To explore the release rate of gossypol acetate from a designed gossypol-loaded intrauterine device (IUD) in mice. METHODS The mice were administrated with gossypol acetate-loaded IUD and then the release rate of gossypol acetate from the IUD was tested by HPLC. RESULTS The results showed that the concentration of plasma gossypol acetate gradually increased to a peak level of 0.30 μg·L^-1 on the second day, which was then maintained for several months. CONCLUSION A gossypol-loaded IUD is a reliable method of administration for gossypol acetate and it is possibly an effective way to treat adenomyosis in mice.