诺氟沙星定量检测分析：基于导电金刚石电极电化学方法

张丹红; 万琳丰; 梁雅琦; 袁晓溪; 李红东

doi:10.13748/j.cnki.issn1007-7693.20252578

诺氟沙星定量检测分析：基于导电金刚石电极电化学方法

Quantitative Detection and Analysis of Norfloxacin: An Electrochemical Method Based on Conductive Diamond Electrode

摘要

摘要:
目的使用硼/氮共掺杂金刚石(boron-nitrogen co-doped diamond，BNDD)电极，分析诺氟沙星的电化学行为并对其定量检测。
方法电化学检测在三电极体系中进行，工作电极为BNDD电极，采用循环伏安法和方波伏安法研究诺氟沙星的电化学行为。
结果在标准缓冲溶液中(pH=6.5)，诺氟沙星氧化峰电流响应值随浓度增加而明显增加，在0.1~10 μmol·L^–1呈线性关系，检测限为0.036 μmol·L^–1。测定方法具有良好的稳定性、重复性、抗干扰性。
结论 BNDD电极电化学测量灵敏度高，综合性能优良，适用于临床医药领域中诺氟沙星药物的高效快速监测。

Abstract:
OBJECTIVE To analyze the electrochemical behavior of norfloxacin and achieve its quantitative detection by using boron-nitrogen co-doped diamond(BNDD) electrode.
METHODS The electrochemical behaviors of norfloxacin were examined by cyclic voltammetry(CV) and differential square wave voltammetry(SWV) in a three-electrode system with a BNDD electrode as the working electrode.
RESULTS In standard buffer solution(pH=6.5), the oxidation peak currents(I_p) of the norfloxacin response increased significantly with the increase of concentration, showing a linear relationship in the range of 0.1 to10 μmol·L^–1, with the low detection limit of 0.036 μmol·L^–1. The established method showed good stability, repeatability and anti-interference ability.
CONCLUSION The BNDD electrode features high electrochemical detection sensitivity and outstanding comprehensive performance, and is suitable for efficient and rapid monitoring of norfloxacin in clinical pharmaceutical fields.

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