Abstract:
OBJECTIVE To explore the effects of different types and amounts of excipients and different preparation methods on the fluidity and hygroscopicity of fermented Cordyceps powder.
METHODS Three kinds of excipients were selected from 10 kinds of excipients. The optimal mixing time and proportion of fermented Cordyceps powder were investigated by means of ultrafine composite particles and physical mixing. The improvement effect of fluidity and hygroscopicity was compared, and the fitting model of hygroscopicity equation was established.
RESULTS According to the comprehensive analysis of powder characteristics, rheological properties and moisture absorption characteristics, three excipients were selected as hydrophobic silica, crosslinked povidone and dextrin. The optimum process parameters obtained by the contact angle are as follows : the excipient-addition ratio-grinding time is SiO2-3%-3 min, cross-linked povidone-1%-1 min, dextrin-1%-1 min.After adding excipients for physical mixing, the moisture resistance and fluidity are good, and the silica effect is the best.
CONCLUSION Adding excipients is a common way to improve the fluidity of fermented Cordyceps powder. Hydrophobic silica has the best improvement effect in all aspects. Secondly, the physical mixing operation is simple, which makes the powder easier to flow. At the same time, the two hygroscopic kinetic models of double exponential model and Weibull model provide a good theoretical basis for the high fitting degree of fermented Cordyceps powder-excipients.
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