Abstract: Biotechnological drugs have experienced rapid development in recent years. As a new type of pharmaceutical packaging material, cyclic olefin copolymer/polymer are gradually being used in the field of biotechnological drugs to prepare packaging systems. Given the complex and ever-changing nature of biotechnological drugs, their compatibility with the packaging systems used has also become a research hotspot. This article mainly introduces the structure and characteristics of existing cyclic olefin copolymer/polymer pharmaceutical packaging systems, as well as the research progress on their compatibility with biotechnological drugs, and looks forward to the future key development directions of their compatibility.