注射用卤化丁基橡胶塞中19种元素分析及研究

刘珊; 訾晓伟; 程磊; 陈瑜; 李彩霞; 谢升谷

doi:10.13748/j.cnki.issn1007-7693.20232639

注射用卤化丁基橡胶塞中19种元素分析及研究

Analysis and Research of 19 Elements in Halogenated Butyl Rubber Stopper for Injection

摘要

摘要:
目的建立电感耦合等离子体质谱法(inductively coupled plasma mass spectrometry，ICP-MS)测定注射用卤化丁基橡胶塞化学性能试验溶液中19种金属元素，并根据各元素分布情况对胶塞质量进行评价。
方法采用 ICP-MS法建立注射用卤化丁基橡胶塞化学性能试验溶液中锂(⁷Li)、硼(¹¹B)、镁(²⁴Mg)、铝(²⁷Al)、钒(⁵¹V)、铬(⁵²Cr)、钴(⁵⁹Co)、镍(⁶⁰Ni)、铜(⁶³Cu)、锌(⁶⁶Zn)、砷(⁷⁵As)、钼(⁹⁵Mo)、镉(¹¹¹Cd)、锡(¹¹⁸Sn)、锑(¹²¹Sb)、钡(¹³⁷Ba)、钨(¹⁸³W)、汞(²⁰¹Hg)、铅(²⁰⁸Pb)共19种元素同时测定的方法，并考察元素分布情况。
结果测定方法中所有元素的线性相关系数(r)均>0.9990，检出限在0.0001~5.000 μg·L⁻¹，重复性和稳定性的相对标准偏差(relative standard deviation，RSD)均<10%，加样回收率在90%~120%。
结论 ICP-MS法可准确同时测定注射用卤化丁基橡胶塞化学性能试验溶液中19种元素含量，为卤化丁基橡胶塞国家标准提高提供参考，为卤化丁基橡胶塞的风险监测提供科学实验基础。

Abstract:
OBJECTIVE To establish an inductively coupled plasma mass spectrometry(ICP-MS) method for the determination of 19 elements in dissolution test of halogenated butyl rubber stopper and the halogenated butyl rubber stopper was evaluated based on the distribution of each element.
METHODS Simultaneous determination of lithium(⁷Li), Boron(¹¹B), Magnesium(²⁴Mg), Aluminum(²⁷Al), Vanadium(⁵¹V), Chromium(⁵²Cr), Cobalt(⁵⁹Co), Nickel(⁶⁰Ni), Vopper(⁶³Cu), Zinc(⁶⁶Zn), Arsenic(⁷⁵As), Molybdenum(⁹⁵Mo), Cadmium(¹¹¹Cd), Tin(¹¹⁸Sn), Antimony(¹²¹Sb), Barium(¹³⁷Ba), Tungsten(¹⁸³W), Mercury(²⁰¹Hg), Lead(²⁰⁸Pb) in dissolution test of halogenated butyl rubber stopper was analyzed by ICP-MS. The distribution of elements was investigated.
RESULTS The linear correlation coefficients(r) of all elements in the method were greater than 0.9990, the detection limits were between 0.0001−5.000 μg·L⁻¹, the relative standard deviations(RSD) of repeatability and stability were all less than 10%, and the spiked recoveries were 90%−120%.
CONCLUSION The method can accurately and simultaneously determine the content of 19 elements in the dissolution test of halogenated butyl rubber stopper by ICP-MS, providing reference for improving the national standard of halogenated butyl rubber stopper and scientific experimental basis for risk monitoring of halogenated butyl rubber stopper.

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