Abstract: OBJECTIVE To establish the rationality evaluation standard of clinical application of dapagliflozin and use the attribute hierarchical model to comprehensively evaluate the rationality of the clinical application of dapagliflozin. METHODS Based on the instructions of dapagliflozin, the relevant guidelines issued by the Chinese Medical Association, or the consensus of experts, the drug use evaluation standard of dapagliflozin was formulated. Attribute hierarchical model was used to analyze and evaluate 268 archived cases of dapagliflozin in Bozhou People’s Hospital from January to September 2021. RESULTS The main irrational problems and proportions of dapagliflozin were administration method(91.0%), usage and dosage(69.4%), pre-medication assessment(60.4%), and medication monitoring(53.7%). There were 16 excellent cases(6.0%) with 90≤medical record score(MRS)<100, 137 good cases(51.1%) with 70≤MRS<90, 94 qualified cases(35.1%) with 60≤MRS<70 and 21 disqualified cases(7.8%) with MRS<60. CONCLUSION The drug use evaluation based on the attribute hierarchical model has simple operation, accurate and credible results. The method integrates multiple evaluation indicators to make the evaluation results more intuitive and can be popularized in the evaluation of clinical applications of drugs.