Abstract: Hypoxia-inducible factor-1α(HIF-1α), as the main regulator of hypoxia response, may play an important role in osteoporosis development, which can regulate the balance between osteoblast-osteoclast metabolism by regulating osteoblast- vascular coupling, estrogen secretion, glycolysis and other processes. It has been shown that HIF-1α is strongly linked with ferroptosis. As a special form of cell death induced by iron-dependent lipid peroxidation, ferroptosis has been implicated in many diseases, such as carcinogenesis, degenerative disease. Recent studies indicated that HIF-1α induced to ferroptosis of bone cell, which is involved in osteoporosis genesis and development. Based on this, this review focused on advances in the molecular regulation mechanism of osteoblasts, osteoclasts, bone marrow mesenchymal stem cells and ferroptosis by HIF-1α, in order to provide more references for clinical diagnosis and treatment.