Abstract: Hyaluronic acid is a linear polysaccharide that is ubiquitous in the human tissues and organs.Furthermore,it is one of the primary components of the extracellular matrix.More recently,hyaluronic acid has become recognized as an important building block for the creation of new biomaterials with utility in biomedical field due to its excellent biocompatibility,anti-adhesion properties,and easy modification of the structure characteristics.This review focuses on recent advances in hyaluronic acid-based antibacterial agents and its medical application,and discusses the roles of hyaluronic acid played in antibacterial agents.The limitations and challenges in the application hyaluronic acid-based antibacterial agents are also pointed out.Finally,some prospects about hyaluronic acid used in antibacterial medicine in the future is proposed.