Abstract: Prostate cancer has become one of the most common cancers in men worldwide. In clinical practice, it is mainly through surgical resection treatment, radiation treatment and drug treatment, but it will produce side effects at the same time. In recent years, traditional Chinese medicine ingredients have obvious curative effects in the treatment of cancer, and relatively few side effects. PI3K/AKT signaling pathway is one of the most classical pathways in cancer, and it is involved in tumor proliferation, cell cycle operation, and migration and invasion. This article summarizes the protective effects of traditional Chinese medicine ingredients in the PI3K/AKT signaling pathway on prostate cancer treatment in recent years by domestic and foreign scholars, aim to provide a basis for the use of Chinese medicine ingredients and drug combination to treat cancer by providing new ideas and treatment strategies.