Abstract: OBJECTIVE To provide reference for clinical pharmacists to carry out pharmaceutical practice through pharmaceutical care of a ICU patient with intracranial infection of Mycobacterial iranicum. METHODS The clinical pharmacist assisted clinicians in making treatment decisions by reasonable interventions for drug interactions and adverse reactions in a case of intracranial infection of ICU patient with Mycobacterial iranicum. RESULTS The clinician adopted the recommendations of the clinical pharmacist and the patient’s later treatment process went smoothly. CONCLUSION Clinical pharmacists should provide reasonable pharmaceutical recommendations for clinical use by paying close attention to drug interactions and adverse reactions to ensure patients’ medication safety.