Abstract: OBJECTIVE To investigate the role of the clinical pharmacist in pharmaceutical care and antithrombotic therapy selection on a patient with cerebral venous sinus thrombosis caused by essential thrombocythemia. METHODS Clinical pharmacist participated in the whole process of drug treatment for a case of cerebral venous sinus thrombosis related to essential thrombocythemia. During the treatment, the clinical pharmacist gave suggestion on antithrombotic therapy regimen and provided entire pharmaceutical care, evaluated the drug efficacy, monitored drug adverse reaction and carried out medication education. RESULTS The limb weakness of the patient had been improved, without headache, nausea, vomiting and twitch after treated with anticoagulation, dehydration and anti-epileptic. And the patient was discharged. There was no adverse drug reactions during treatment, such as skin and mucous plaque, gingival bleeding, hemorrhinia and melena. CONCLUSION Clinical pharmacists provide pharmaceutical care for patients with cerebral venous sinus thrombosis can promote the efficacy and safety of medication and improve the compliance.