Abstract: OBJECTIVE To develop a software for individualizing dosage regimens of oxcarbazepine(OXC) based on the population pharmacokinetics(PPK) models. METHODS OXC dosing software was developed by MyEclipse, SQL Server, JRE and so on, according to the monohydroxycarbazepine(MHD)'s PPK model of adults and children. The software developing schemes included requirement analysis, general design, detailed design, software coding, software test, software maintenance and software redevelopment. RESULTS The software was able to input and manage patient information, run NONMEM automatically, predict blood concentrations under various dosing regimens which could help initial dosage design, and predict blood concentrations more accurately based on therapeutic drug monitoring results and Bayesian method in dosage adjustment. CONCLUSION This new developed software based on MHD's PPK models can give assistance to facilitate the individualized therapy for epilepsy patients expediently.