Abstract: OBJECTIVE To study the processing of Chinese herbal medicine Ilex hainanensis Merr. produced in Guangxi, and to carry out an experimental study on its antihypertensive effect. METHODS Ilex hainanensis Merr. was processed by different processing. The effects of different processed products of Ilex hainanensis Merr. on the blood pressure of spontaneously hypertensive rats(SHR) were measured by tail artery method. RESULTS Five types of Ilex hainanensis Merr. processed products were obtained. Compared with the model group, the different processing Ilex hainanensis Merr. had obvious effect of lowering blood pressure. For different microwave processed varieties, the antihypertensive effect of 60 g microwave 11 min group was the best. CONCLUSION The best microwave processing technology of Ilex hainanensis Merr. is microwave of 60 g of medicinal materials for 11 min. The Ilex hainanensis Merr. prepared by this method has the best antihypertensive effect on SHR.