Abstract: OBJECTIVE To study the migration of 15 elements(Pt, Fe, Mn, Cr, Mo, Cd, Pb, As, Hg, Co, Ni, V, Cu, Sb and P) in the Compound Sodium Chloride injection from its production pipeline and to evaluate its safety. METHODS ICP-MS was used to perform the analysis. The radio frequency power was 1 550 W; the speed of the peristaltic pump was 40 r·min^-1; the temperature of the atomization chamber was 2.7℃; the sampling depth was 5 mm; the cooling airflow speed was 14 L·min^-1 and the auxiliary airflow velocity was 0.800 0 L·min^-1. RESULTS The r of 15 elements was 0.998 8-0.999 9; the recovery rate was 75%-120%; the RSD of the precision experiment of instrument was 1.3%-8.5%; the RSD of the repetitive experiment was 2.2%-15%; and the daily intake of 15 elements in the determination of 3 batches of sample migration was lower than their corresponding permitted daily exposure(PDE). CONCLUSION The method is simple and reliable. It can be used to determine the migration of 15 elements in the Compound Sodium Chloride injection from its production pipeline.