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    奥氮平所致药物不良反应的发生率及相关影响因素研究

    Research on the Incidence of Adverse Drug Reactions and Related Influencing Factors Caused by Olanzapine

      摘要
    • 摘要: 目的 调查奥氮平所致药物不良反应（adverse drug reactions，ADRs）的发生情况，并探讨其影响因素。方法 选取厦门市精神卫生中心接受治疗的1 691例精神障碍患者，监测治疗过程中奥氮平ADRs的发生情况，采取单因素和多因素分析方法，研究奥氮平ADRs发生的相关影响因素。结果 奥氮平ADRs发生率较高，为33.83%。多因素非条件Logistic回归分析发现有肝病史、服用高剂量药物（>10mg）是奥氮平所致ADRs发生的危险因素，OR值分别为1.824（95% CI：1.155~2.882）和4.910（95% CI：3.943~6.113）。结论 有肝病史及服用高剂量药物（>10 mg）的精神疾病患者是奥氮平ADRs发生的高危人群。

       

      Abstract: OBJECTIVE To investigate the occurrence of adverse drug reactions(ADRs) caused by olanzapine, and then explore its influencing factors. METHODS A total of 1 691 patients with mental disorders treated in Xiamen Mental Health Center were selected to monitor the occurrence of olanzapine ADRs in the treatment process, and the related influencing factors of olanzapine ADRs were studied by single-factor and multi-factor analysis. RESULTS Olanzapine had a higher incidence of ADRs(33.83%). Patients with liver disease history and taking high-dose drugs(>10 mg) were risk factors for ADRs through multivariate unconditional Logistic regression analysis, and the OR values were 1.824(95% CI:1.155-2.882) and 4.910(95% CI:3.943-6.113), respectively. CONCLUSION Patients with liver disease history and high dose of drugs(> 10 mg) are the high-risk groups for ADRs induced by olanzapine.

       

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