Abstract: The patients with both COVID-19 and basic diseases have to take multiple medications. In order to reduce the drug interaction, improve the effect of medical treatment, and reduce the incidence of adverse drug reactions in patients, the drug interactions between antiviral drugs included in the National Health and Health Commission’s Diagnostic and Treatment Scheme for COVID-19(Trial Version 7) and other therapeutic drugs are elaborated in this article. Based on this, this article also offer a proposal on pharmaceutical care, hoping to provide medication advice for the rational clinical treatment.