畲药白山毛桃根抗肿瘤作用及活性成分研究进展

    Research Progress of Anti-tumor Effects and Active Constituents of Actinidia Eriantha Benth. Root

    • 摘要: 目的 综述畲药白山毛桃根抗肿瘤作用及活性成分研究进展,为白山毛桃根的临床应用和进一步开发提供参考依据。方法 检索1980—2018年以来国内外有关白山毛桃根的抗肿瘤作用及活性成分的研究论文,总结分析其抗肿瘤作用、抗肿瘤机制及活性成分。结果 白山毛桃根具有治疗胃癌、肝癌、黑色素瘤等多种抗肿瘤作用,其作用机制包括诱导细胞凋亡和坏死、免疫调节、阻滞细胞周期等,其抗肿瘤活性成分主要为乌苏酸类化合物。结论 白山毛桃根具有良好的抗肿瘤作用,临床应用价值较高,尚需加强其循证医学数据、抗肿瘤活性成分和质量标准的深入研究。

       

      Abstract: OBJECTIVE To review the research progress of anti-tumor effects and active constituents of Actinidia eriantha Benth., in order to provide reference for the clinical application and further development of Actinidia eriantha Benth. root. METHODS The researches on anti-tumor and active constituents of Actinidia eriantha Benth. root from 1980 to 2018 were searched. The anti-tumor effect, mechanism and anti-tumor active ingredients were summarized and analyzed. RESULTS Actinidia eriantha Benth. root had various anti-tumor effects such as gastric cancer, liver cancer, nasopharyngeal carcinoma and cervical cancer. Its anti-tumor mechanism included regulating the expression of apoptosis-related genes, regulating immune regulation, arresting cell cycle and inhibiting proliferation and inducting apoptosis and necrosis, etc. Its anti-tumor active components were mainly triterpenoids. CONCLUSION Actinidia erantha Benth. root has good anti-tumor effect and high clinical value. It is necessary to strengthen its evidence-based medical data and in-depth study of anti-tumor active ingredients.

       

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