Abstract: OBJECTIVE To study the significance, working method and effect about specialized clinical pharmacists ward round based on rotation mode. METHODS Specialized clinical pharmacists real-time provided medication guidance for clinicians by surgical ward round based on rotation mode, and carried out pharmaceutical intervention according to problems of clinical medication. RESULTS Clinical pharmacists could correct clinical medication problems of surgery such as antimicrobial, antitumor, anticoagulant/hemostatic and adjuvant drugs. Moreover, clinical pharmacists strengthened communication with medical staff and enhanced subjective initiative of clinical pharmacy work. After rotation ward round, the percentage of medication rationality in surgery increased from 80.1% to 94%, with significant difference(P<0.05). CONCLUSION Specialized clinical pharmacists can effectively solve medication problems and improve standardization and rationality of medication by rotation ward round in surgery.