Abstract: OBJECTIVE To strengthen the management of the clinical utilization of carbapenems antibiotics and tigecycline in Nanyang First People's Hospital, analyze and evaluate its management effectiveness. METHODS The antibiotics usage rate, the mean hospital stay, the mean cost of antibiotics, the proportion of expenses, the proportion of sales of various varieties, and submission rates of microbiological specimen of the patients who were treated with carbapenems and tigecycline before and after the administration in our hospital between January 1, 2016 and June 30, 2018 were retrospectively analyzed. RESULTS The median usage rate of total antimicrobial agents and carbapenems before and after administration were significantly decreased from 54.12% and 1.69% to 50.44% and 1.30%, respectively(P<0.05). After strengthening the management, the median cosy of antibiotics per patient was 1 095.75 yuan, which was lower than the 1 190.83 yuan before the strengthening of management(P<0.05). The cost of carbapenems and tigecycline as a proportion of total drug cost and total treatment costs before and after administration were significantly decreased from 2.09%, 0.84% to 1.81%, 0.66%, respectively(P<0.05). The submission rates of microbiological specimens efore general, special therapeutic antimicrobial use, carbapenems and tigecycline increased from 32.03%, 81.34% and 85.31% of pre-intervention respectively to 36.17%, 85.99% and 92.95% of postintervrntion respectively(P<0.05). CONCLUSION Comprehensive intervention measures of carbapenems and tigecycline can significantly reduce the use rate of these drugs and the mean cost of antibacterial agents, improve the submission rates of microbiological specimens before therapeutic use of antimicrobial agents, and there is no significant change in average hospital stay.