姜黄素修复脊髓损伤的信号通路研究进展

Research Progress in Signal Pathway of Curcumin for Repairing Spinal Cord Injury

摘要: 姜黄素是从中药姜黄中提取的天然多酚化合物，对于脊髓损伤的修复显示出良好的疗效。姜黄素可以抑制神经炎症反应；减少胶质瘢痕的形成；减少局部神经组织自由基释放和脂质过氧化；减少神经细胞凋亡和改善脊髓损伤微环境。综述目前姜黄素修复脊髓损伤研究所涉及8条信号通路（NF-κB、TLR4-TAK1-NF-κB、JAK/STAT、Nrf2、ERS、N-甲基-D-天冬氨酸受体-Ca²⁺诱导型一氧化氮合酶、SOX9和Wnt/β-catenin）及相关具有潜力的通路（mTOR），为姜黄素治疗脊髓损伤作用机制的深入研究提供新思路。

Abstract: Curcumin is a natural polyphenolic compound extracted from turmeric of traditional Chinese medicine and shows good curative effect on the repair of spinal cord injury. Curcumin can inhibit the neuroinflammatory reaction, reduce glial scar formation, reduce local nerve tissue free radical release and lipid peroxidation, reduce nerve cell apoptosis and improve the spinal cord injury microenvironment. In this review, eight signaling pathways involved in the treatment of spinal cord injury with curcumin(NF-κB, TLR4-TAK1-NF-κB, JAK/STAT, Nrf2, ERS, N-Methyl-D-aspartate receptor-Ca²⁺ inducible nitric oxide synthase, SOX9 and Wnt/β-catenin) and one related potential pathway(mTOR), provide new ideas for further study of the mechanism of curcumin in spinal cord injury treatment.