Abstract: OBJECTIVE To study the effect of alkaline drugs on the inner surface of direct contact borosilicate glass bottles, and investigate the compatibility of pharmaceutical packaging and drugs. METHODS The inner surface of low borosilicate glass injection bottle filling Parecoxib Sodium for Injection was observed by scanning electron microscopy, and combined with X-ray spectrometer confirmed erosion position. RESULTS Based on the scanning electron microscope (SEM) study of the inner surface of low borosilicate glass injection bottle, showed that the positive control sample was able to distinguish different erosion degrees, and no obvious erosion occurred in the samples in each period of the accelerated test. CONCLUSION Scanning electron microscope combined with X-ray spectrometer can visually show the extent of the erosion of the inner surface structure of low borosilicate glass injection by contact drug, and can be used as the basis for evaluating the compatibility of pharmaceutical packaging and drugs.