Abstract: OBJECTIVE To explore the effect of oleanolic acid(OA) on the metabolism of fluvastatin in rats. METHODS Sixteen health rats were randomly divided into two groups: the single group(fluvastatin 5.0 mg·kg^-1) and the combined group(fluvastatin 5.0 mg·kg^-1+OA 60 mg·kg^-1). The single group were administrated with blank solution while the combined group were administrated with the same volume of OA, the administration period of 5 d. At the sixth day, both groups were administrated with fluvastatin, plasma concentrations of fluvastatin were determined by LC-MS. The main pharmacokinetic parameters were calculated and compared. RESULTS The main pharmacokinetic parameters(C_max, AUC_0-t) of the combined group showed increased remarkably compared with the single group. Statistically significant difference was showed between groups(P<0.05). CONCLUSION OA can affect the pharmacokinetic parameters of fluvastatin in rats.