FGF21对大鼠肝癌模型中TGF-β信号通路的影响

江松敏; 陈智心; 蔡琳<sup>*</sup>

引用本文:	江松敏,陈智心,蔡琳.FGF21对大鼠肝癌模型中TGF-β信号通路的影响[J].中国现代应用药学,2014,31(3):261-265.
	JIANG Songmin,CHEN Zhixin,CAI Lin.Effect of FGF21 on TGF-β Signaling Pathway in Rat Liver Cancer[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(3):261-265.

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FGF21对大鼠肝癌模型中TGF-β信号通路的影响
江松敏¹, 陈智心², 蔡琳²
1.瑞安市人民医院，浙江瑞安 325200;2.温州医科大学药学院，浙江温州 325035

摘要:

目的研究FGF21通过TGF-β/Smads信号通路延缓肝癌发生发展的分子机制。方法采用Western blot法检测各组大鼠肝癌组织的TGF-β1, TGF-β RⅡ, Smad 2,3,4,7的蛋白表达水平，采用Q-PCR法检测各组大鼠肝癌组织的TGF-β1, TGF-β RⅡ, Smad 2,3,4,7的mRNA表达水平。结果在不同FGF21浓度下，TGF-β1，TGF-β RⅡ，Smad 2,3,4,7表达水平不同(P<0.05)。结论 FGF21通过促进TGF-β/Smads信号通路中的信号分子或受体的表达，或者通过下调此信号通路的阻断分子而抑制肿瘤发生。

关键词: FGF21 TGF-β1 Smad

DOI：

分类号:

基金项目:浙江省教育厅科研项目(Y200907097)；温州市科技计划项目(Y20090257)

Effect of FGF21 on TGF-β Signaling Pathway in Rat Liver Cancer

JIANG Songmin¹, CHEN Zhixin², CAI Lin²

1.Ruian People’s Hospital, Ruian 325200, China;2.School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China

Abstract:

OBJECTIVE To research the possible molecular mechanisms of FGF21 via TGF-b/Smads signal pathway to delay the development of liver cancer. METHODS Detect the protein expressions of TGF-β1, TGF-β RⅡ, Smad 2,3,4,7 of respective rats cancer tissue with Western blot and detect the mRNA expression of TGF-β1, TGF-β RⅡ, Smad 2,3,4,7 of respective rats cancer tissue with Q-PCR. RESULTS The expressions of TGF-β1, TGF-β RⅡ, Smad 2,3,4,7 varied with the different concentrations of FGF21(P<0.05). CONCLUSION By promoting TGF-β/Smads signaling pathway in the expression of signaling molecules or receptors, or by decreasing the blocking of this signaling pathway, tumor was inhibited by FGF21.

Key words: FGF21 TGF-β1 Smad