| 引用本文: | 杨继鸿,张国亮,李丛舒,骆光鑫,徐靖,王瑛,史月姣,李振皓.去壁灵芝孢子粉片的含量测定与免疫调节及心脏保护功能研究[J].中国现代应用药学,2024,41(2):203-212. |
| YANG Jihong,ZHANG Guoliang,LI Congshu,LUO Guangxin,XU Jing,WANG Ying,SHI Yuejiao,LI Zhenhao.Study on Content Determination and Immunomodulatory and Cardioprotective Effects of Sporoderm-Removed Ganoderma Lucidum Spore Powder Tablet[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(2):203-212. |
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| 去壁灵芝孢子粉片的含量测定与免疫调节及心脏保护功能研究 |
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杨继鸿1, 张国亮2, 李丛舒1, 骆光鑫1, 徐靖2, 王瑛3, 史月姣3, 李振皓1,2
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1.浙江寿仙谷植物药研究院有限公司, 杭州 311100;2.浙江省珍稀植物药工程技术研究中心, 浙江 武义 321200;3.寿仙谷珍稀药材产品省级重点农业企业研究院, 浙江 武义 321200
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| 摘要: |
| 目的 研究并评价“仙芝3号”去壁灵芝孢子粉片的免疫调节和心脏保护作用。方法 首先运用UPLC-Q-TOF-MS和比色法分析“仙芝3号”去壁灵芝孢子粉片的主要化学成分，考察其对斑马鱼巨噬细胞减少症模型、斑马鱼心衰模型、H2O2诱导的心肌及内皮细胞氧化应激模型、脂多糖诱导的小胶质细胞炎症模型的影响，通过巨噬细胞形成能力、巨噬细胞吞噬能力、抗神经炎症能力、心脏收缩舒张改善能力、抗心肌及内皮细胞氧化应激损伤能力等多个指标评估其免疫调节及心脏保护作用。结果 “仙芝3号”去壁灵芝孢子粉片可以提高巨噬细胞形成及吞噬能力，改善心脏收缩舒张功能，减少神经炎症并缓解心肌及内皮细胞因氧化应激而造成的损伤，从而起到免疫调节和心脏保护作用。结论 “仙芝3号”去壁灵芝孢子粉片有望用于免疫功能调节及心脏功能保护。 |
| 关键词: 去壁灵芝孢子粉片 免疫调节 心脏保护 |
| DOI：10.13748/j.cnki.issn1007-7693.20231137 |
| 分类号:R284.1；R285.5 |
| 基金项目: |
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| Study on Content Determination and Immunomodulatory and Cardioprotective Effects of Sporoderm-Removed Ganoderma Lucidum Spore Powder Tablet |
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YANG Jihong1, ZHANG Guoliang2, LI Congshu1, LUO Guangxin1, XU Jing2, WANG Ying3, SHI Yuejiao3, LI Zhenhao1,2
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1.Zhejiang Shouxiangu Botanical Drug Institute Co., Ltd., Hangzhou 311100, China;2.Zhejiang Engineering Research Center of Rare Medicinal Plants, Wuyi 321200, China;3.Zhejiang Key Agricultural Enterprise Institute of Shouxiangu Rare Herb Products, Wuyi 321200, China
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| Abstract: |
| OBJECTIVE To investigate the potential therapeutic effect of the sporoderm-removed Ganoderma lucidum spore tablet "Xianzhi No.3" from the perspective of immunomodulation and cardioprotection. METHODS Chemical components of the sporoderm-removed Ganoderma lucidum spore tablet "Xianzhi No.3" were analyzed by UPLC-Q-TOF-MS and colorimetric methods. Examined tablet’s effects on zebrafish models of macrophage reduction, heart failure, H2O2-induced oxidative stress in myocardial and endothelial cells, and a microglial inflammation model induced by lipopolysaccharide. Immune regulation and cardioprotective effects were evaluated through multiple indicators, including macrophage formation and phagocytosis abilities, anti-neuroinflammation ability, cardiac systolic and diastolic functions, and anti-oxidative stress injury ability in myocardial and endothelial cells. RESULTS The sporoderm-removed Ganoderma lucidum spore tablet "Xianzhi No.3" improved macrophage formation and phagocytosis, cardiac systolic and diastolic functions, reduced neuroinflammation, and alleviated oxidative stress in myocardial and endothelial cells, resulting in immunomodulatory and cardioprotective effects. CONCLUSION The sporoderm-removed Ganoderma lucidum spore tablet "Xianzhi No.3" maybe a potential therapeutic agent for regulating the immune system and protecting cardiac function. |
| Key words: sporoderm-removed Ganoderma lucidum spore tablet immunomodulation cardioprotection |
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