| 引用本文: | 吴孔阳,朱玉杰,唐琳,陈雪冬,钟洁,杨梅,杨同香.灵菌红素递送系统研究进展[J].中国现代应用药学,2023,40(1):139-144. |
| WU Kong-yang,ZHU Yu-jie,TANG Lin,CHEN Xue-dong,ZHONG Jie,YANG Mei,YANG Tong-xiang.Research Progress on the Delivery Systems of Prodigiosin[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(1):139-144. |
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| 灵菌红素递送系统研究进展 |
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吴孔阳1, 朱玉杰1, 唐琳1, 陈雪冬1, 钟洁1, 杨梅1, 杨同香2
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1.洛阳师范学院生命科学学院, 河南 洛阳 471934;2.河南科技大学食品与生物工程学院, 河南 洛阳 471023
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| 摘要: |
| 灵菌红素(prodigiosin,PG)是由微生物次级代谢产生的一类红色素,具有抗肿瘤作用,抗菌、抗疟疾、抑藻、杀虫和免疫抑制活性等诸多生物学功能,然而PG难溶于水,稳定性较差,易被破坏等限制其功能发挥。因此明确PG结构、特性及递送体系统刻不容缓。本文从PG结构进行介绍,对现有输送体系进行归纳分析,以期了解PG、增强其功能特性,为进一步扩大PG在医药和食品领域的应用提供理论支撑。 |
| 关键词: 灵菌红素 生理功能 稳定性 递送系统 |
| DOI：10.13748/j.cnki.issn1007-7693.2023.01.021 |
| 分类号:R945 |
| 基金项目:河南省高等学校重点科研项目(20A180018,21A180017,22B210006);国家大学生创新创业训练计划项目(202110482035X);洛阳师范学院应用科学与技术研究基金项目(2018-YYJJ-003);教育部产学研协同育人项目(202101228068) |
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| Research Progress on the Delivery Systems of Prodigiosin |
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WU Kong-yang1, ZHU Yu-jie1, TANG Lin1, CHEN Xue-dong1, ZHONG Jie1, YANG Mei1, YANG Tong-xiang2
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1.College of Life Science, Luoyang Normal University, Luoyang 471934, China;2.College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China
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| Abstract: |
| Prodigiosin(PG) represents a family of occurring red pigments produced by microbial secondary metabolism. PG has been demonstrated valuable biological activities as antitumor effect, antibacterial, antimalaria, antialgae, anti-insect and immunosuppressive activities. However, PG is insoluble and/or hardly soluble in water, poor stability, easier degradation and limit its ability to treat in functional status. Therefore, it is urgent to clarify the structure, characteristics and transport system of PG. This paper analyzed the structure of PG and summarized the existing transportation systems in order to understand PG and improve function, so as to provide theoretical support for further expanding the application of PG in medicine and food field. |
| Key words: prodigiosin physiological function stability delivery systems |
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