Determination of Acrylic Acid in Carbomer Copolymer by HPLC

OBJECTIVE To establish an HPLC method for the determination of acrylic acid in carbomer copolymer. METHODS The samples were separated on Sepax GP-C₁₈ column (4.6 mm×250 mm, 5 μm) eluted with potassium dihydrogen phosphate-methanol(80∶20) as mobile phase. The isocratic elution was used at a flow rate of 1.0 mL·min^-1, the detection wavelength was 200 nm, the column temperature was 30 ℃. RESULTS The calibration curve was linear in the range of 0.327 5-32.75 μg·mL^-1 for acrylic acid with r=0.999 6, the average recovery was 93.02%. CONCLUSION The method is accurate and reliable, and can be applied for the quality control of acrylic acid in carbomer copolymer.