Study on the Stability of Potassium Dehydroandrograpolide Succinate Injection in Clinical Common Transfusion

OBJECTIVE To investigate the compatibility conditions of potassium dehydroandrograpolide succinate injection combined with clinical common transfusion. METHODS Selected temperature, illumination, storage time and solvent as factor, the content of potassium dehydroandrograpolide succinate, pH value changes of the compatibility solution and the insoluble particles was used as indexes. The limits of the related substances of potassium dehydroandrograpolide succinate in the compatibility solution were also investigated. RESULTS In 4 h, potassium dehydroandrograpolide succinate injection could be combined with 5% glucose injection and 0.9% sodium chloride injection, and was incompatible with 5% glucose and sodium chloride injection. CONCLUSION Potassium dehydroandrograpolide succinate injection can be combined with 5% glucose injection and 0.9% sodium chloride injection in 4 hours. But should try to avoid sunlight exposure and high temperature environment.