Protective Effects of Silybin Self-emulsifying Drug Delivery Systems on Acute Liver Injury Induced by CCl4

OBJECTIVE To explore the protective effects of silybin self-emulsifying drug delivery systems on acute liver injury induced by CCl₄. METHODS Saline and bifendate were selected as negative and positive control, respectively. The protective effects of silybin self-emulsifying drug delivery systems on acute liver injury induced by CCl₄ was evaluated by the levels of ALT and AST in plasma, glutathione peroxidase in liver and liver histopathology, and compared with silybin suspension. RESULTS Silybin self-emulsifying drug delivery systems inhibited the increase of the ALT and AST in serum markedly, maintained the normal level of GSH-PX in liver and protect liver from lesion. Conclusion Silybin self-emulsifying drug delivery system has protectived effect on acute liver injury induced by CCl₄.