Preparation of Lidocaine Nano Silica Surface Molecular Imprinted Polymers and Its Binding Characteristics

OBJECTIVE To prepare lidocaine nano silica surface molecular imprinted polymers using molecular imprinting technique, and explore its adsorption properties for selective adsorption and enrichment of lidocaine. METHODS A nano silica surface molecular imprinted polymer was prepared by sol-gel method, in which lidocaine was template molecule. Equilibrium binding experiment was used to investigate the adsorption dynamics, the binding ability to template molecule and the substrate selectivity. The Scatchard analysis was used to study that the MIPs’ binding characteristic to template molecule. RESULTS Compared with the same chemical composition of non imprinted polymer, the polymer had good adsorption. CONCLUSION Systematic study on recognition properties of nano silica surface molecular imprinted polymer is carried out. It is found that the imprinted polymer shows good binding characteristics to lidocaine.