Preparation and in Vitro Permeation of Edaravone Gel

OBJECTIVE To prepare edaravone transdermal gel and to study its permeation ability in vitro. METHODS The skin permeation ability was evaluated by Valian-Chien permeation cells with isolated rat skin. The concentration of edaravone in samples was determined by HPLC to study the effect of different drug content, laurocapram amount, type and content of the cyclodextrin. RESULTS The optimal form ulation was composed with 6% edaravone, 10% laurocapram, 10% β-cyclodextrin, and 2% sodium carboxymethyl cellulose. The accumulative permeation amount of the gel was (501.95±27.59)μg·cm^-2 in 12 h, and the permeation rate was (42.25±7.39)μg·cm^-2·h^-1. CONCLUSION Edaravone gel prepared in the study would be developed as a novel transdermal preparation.