Pharmacokinetics of Propofol in Pigs with Hemorrhagic Shock Under Volume Controlled

OBJECTIVE to investigate the characteristics of pharmacokinetics of propofol in pigs with hemorrhagic shock under volume controlled. METHODS twelve bama mini pigs were randomly divided into control group, hemorrhagic shock group. The plasma concentration of propofol in pigs was analyzed by HPLC-fluorescence at different time points after the start of the infusion propofol. According to the plasma concentration of propofol to calculate the elimination half-life (t_1/2) of propofol, the plasma-effect site equilibration rate content (K_e0), the drug’s area under the curve (AUC), the mean residence time (MRT) and the other pharmacokinetic parameters. RESULTS Plasma concentration of propofol in hemorrhagic shock group was higher than control group significantly(P<0.05). Maximum drug concentration(C_max) in hemorrhagic shock group was higher than control group significantly(P<0.05). The t_1/2 in hemorrhagic shock group was longer than control group significantly(P<0.05). The MRT in hemorrhagic shock group was longer than control group significantly(P<0.05). The K_e0 and AUC of hemorrhagic shock group was higher than that of control group, there was not significant difference between groups. CONCLUSION The characteristic of pharmacokinetics of propofol in pigs with hemorrhagic shock under volume controlled was that metabolism delayed, elimination half-life was longer, so dose the mean residence time, the plasma-effect site equilibration rate content was diminished.