Sedative and Anti-fatigue Effects of Kebai Particles

OBJECTIVE To determine the sedative and anti-fatigue effects of Kebai particles. METHODS Mice were treated with 2.26, 4.52, 9.04 g·kg^-1 Kebai particles orally to determine the influence on nervous system, swimming time and hypoxia tolerance ability of animals. RESULTS Three dosages of Kebai particles had no obvious influence on spontaneous activity and coordinated movement in mice, while high dosage of Kebai particles (9.04 g·kg^-1) had influence on sleep latency period and sleep duration, and could prolong the hypoxia tolerance time (P<0.05). Kebai particles could significantly prolong the swimming time of mice at the doses of 9.04, 4.52 g·kg^-1. CONCLUSION Kebai particles has sedative and anti-fatigue effect.