Preparation and Characterization of Butylphthalide-sulfobutyl-β-cyclodextrin Inclusion Complex

OBJECTIVE To preparae butylphthalide-sulfobutyl-β-cyclodextrin inclusion complex and examine its structure and property. METHODS The inclusion complex was prepared by freeze-drying method. The encapsulation efficiency, content, solubility and dissolution rate of the inclusion complex were determined by ultraviolet spectroscopy. And it was characterized the formation by thin layer chromatography, ultraviolet spectroscopy, infrared spectroscopy, differential scanning calorimetry. The optimum inclusion ratio was determined by phase solubility studies. The Changes of dissolution rate after inclusion complex forming were determined by dissolution test. RESULTS Sulfobutyl-β-cyclodextrin could react with butylphthalide forming the 1∶1 host-guest complex. The encapsulation efficiency was (56.70±1.5)% and the mean drug content was (5.02±1.6)%. CONCLUSION The technique of preparing butylphthalide-sulfobutyl-β-cyclodextrin inclusion complex was simple, which could effectively improve solubility and dissolution rate of butylphthalide.