Application of Crystalline Powder Modification for Sulpiride in Direct Compression

OBJECTIVE To improve the crystalline micromeritic properties of sulpiride, to meet the requirements of direct compression. METHODS The crystal sulpiride was milled to the particles through a 100 mesh screen, using 2% HPMC as modifier, the granules were formed by the bonding effect in a suitable stirring, then dried, sieved, mixed with commonly excipients for direct compression, disintegrant, as well as lubricant, tabletted. RESULTS The characteristics of the modified product were obviously improved, that included the angle of repose, the Carr’s index, the fluidity, and the prepared tablets using the modified product had a good hardness and dissolution. CONCLUSION The satisfactory compression effect is obtained by this method in sulpiride tablets even if the API attained to 79%. Thus, it is possible that the method further is expand application on the direct compression in insoluble drugs of the high API quantity.