Research Progress of Regulating Effects of Dvl on Bone Erosion in Rheumatoid Arthritis by Crosstalk Between Wnt and NF-κB Signalling Pathway

The Wnt signalling cascades have essential roles in development, growth and homeostasis of skeleton through regulating osteoblasts and osteoclasts. Lack or excessive of Wnt signalling pathway activation could impair repair of erosion of rheumatoid arthritis. NF-κB is a kind of multi-directional regulation of transcription factors, involved in a variety of physiological functions like cell growth, development and apoptosis. Inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis. Dvl is a key protein in the Wnt signaling pathway, and studies have found that it is also involved in the regulation of NF-κB pathway. Therefore, research on crosstalk between Wnt and NF-κB signalling pathway and its associates may facilitate development of specific therapeutic interventions for rheumatoid arthritis targeting the two pathway.