Progress on Enantioselective Liquid-Liquid Extraction

OBJECTIVE To introduce the principle of enantioselective liquid-liquid extraction, and to review the progress on enantioselective liquid-liquid extraction in recent years. METHODS The recent progress on enantioselective liquid-liquid extraction was systematically reviewed according to the classification of chiral selectors. RESULTS Five typical types of chiral selector were summarized, including transitional metal complexes, tartaric acid derivatives, crown ethers, β-cyclodextrin derivatives and cinchona alkaloids. Meanwhile, studies on modeling and reaction kinetics of this technique were mentioned. CONCLUSION Enantioselective liquid-liquid extraction is an ideal resolution technology for preparative enantioseparation of racemates due to its high separation efficiency and ease-to-be scaled up characteristics.