Effect of Rutin on Oxidative Stress of Acute Lung Injury Induced by Lipopolysaccharide

OBJECTIVE To investigate the effects of rutin on oxidative stress of acute lung injury induced by lipopolysaccharide(LPS). METHODS Fifty male C57 mice were randomly divided into five groups: control group, model group, and rutin low, middle, high(25, 50, 100 mol·kg^-1) groups. After 6 h of LPS injected, collecting arterial blood for blood gas analysis and lung tissue to examine pathological change, Wet/Dry, the expression of MDA and the activity of CAT, GPx and SOD. RESULTS Compared with the control group, the pathological change and Wet/Dry of lung tissue, the p(CO₂) and respiratory rate(RR), the expression of MDA in lung tissue were dose-increased, while the p(O₂), pH and the activity of CAT, GPx and SOD were decreased. compared with the model group, the pathological change and Wet/Dry of lung tissue, the p(CO₂) and RR, the expression of MDA in lung tissue in rutin groups were concentration-dependent decreased, while the p(CO₂), pH and the activity of CAT, GPx and SOD were concentration-dependent increased. CONCLUSION Rutin pretreatment can concentration- dependent decrease LPS induced acute lung injury by suppressing oxidative stress.