LI Shan, SHENG Rong, HU Yongzhou. Recent Progress of Prolyl Hydroxylase Domain Inhibitors[J]. Chinese Journal of Modern Applied Pharmacy, 2015, 32(10): 1277-1285.
    Citation: LI Shan, SHENG Rong, HU Yongzhou. Recent Progress of Prolyl Hydroxylase Domain Inhibitors[J]. Chinese Journal of Modern Applied Pharmacy, 2015, 32(10): 1277-1285.

    Recent Progress of Prolyl Hydroxylase Domain Inhibitors

    • Hypoxia inducible factor(HIF) is the key transcriptional factor of cellular response to hypoxia and plays a critical role in hypoxia related diseases. When tissue ischemic and inflammation occured, HIF stabilization can be observed and beneficial to tissue stress and injury. Prolyl hydroxylase domain (PHD) selectively hydroxylate proline residues of HIF and act as the most important proteasomal degradation enzyme for HIF in vivo. Thus, PHD inhibition is effective in the treatment of ischemic and inflammatory events through HIF stabilization. In this short review, we will introduce the recent progress of PHD inhibitors.
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