Clinical Efficacy of Mannatide Combined with Tacrolimus Treatment on Vitiligo

OBJECTIVE To evaluate the clinical efficacy of mannatide combined with tacrolimus treatment on vitiligo. METHODS All of 100 patients with vitiligo were randomly divided into observation group(n=50) and control group(n=50). The mannatide combined with tacrolimus was used in observation group and tacrolimus was used in control group. The clinical efficacy, peripheral blood T lymphocyte?subpopulation, serum interleukin-6 (IL-6) level and interferon-γ(IFN-γ) level were compared between the 2 groups. RESULTS The clinical efficacy of control group and observation group was 62.0% and 90.0%, respectively, the difference showed statistically significant (P<0.05). After treatment, the CD4+, CD8+, CD4+/CD8+ of observation group respectively was (44.9±3.6)%, (30.5±3.0)%, (1.9±0.2), IFN-γ and IL-6 was (38.5±4.7), and (109.9±6.2)ng·L^-1, those of control group was(37.2±3.4)%, (35.7±2.7)%, (1.6±0.2) and (65.0±5.0), and(89.4±7.5)ng·L^-1, the difference all showed statistically significant(P<0.05). CONCLUSION Using mannatide combined with tacrolimus treatment on vitiligo has definite effect, regulating the immune balance is its possible mechanism.