Research on the Correlation Between the Dissolution Change of Sulpiride Tablet and Its Material

OBJECTIVE Through the research on the correlation between the dissolution change of sulpiride tablet and its material, to pinpoint the causes of the dissolution decrease in the sulpiride tablets. METHODS The 3 batches of sulpiride that had been used to the research were recrystallized by 50% alcohol, to compare the melting range before and after crystallization, and to confirm whether there are differences between each batch of materials. RESULTS After recrystallization, for all batches, the contents of sulpiride were remain basically unchanged, but the batch pertaining to the dissolution change, melting range had shortened from 2.3 ℃ to 0.5 ℃. The results showed that the 3 batches of sulpiride were different. CONCLUSION Based on the test results and related literatures analysis, researchers came to the conclusion that polymorphism might exist in sulpiride. The dissolution decrease of sulpiride tablet in the investigational period may be due to the crystal transformation of mixed crystal materials.