Meta-analysis of Additional Pseudomonas Aeruginosa Injection for Malignant Tumor

OBJECTIVE To evaluate the efficacy and safety of pseudomonas aeruginosa injection (PAI) for malignant tumor. METHODS Online databases including Cochrane Library, PubMed, Embase, CBM, CNKI, VIP and WANFANG were searched, and relevant randomized controlled trials (RCTs) investigating PAI for malignant tumor were included. Jadad scale was used to assess literature quality and Revman 5.3 was used to analyze data. RESULTS Fourteen RCTs with 1 036 patients were included (PAI group, 526 cases; control group, 510 cases). Compared with control group, PAI achieved better results in aspects of complete remission(CR) RR=1.64, 95%CI=1.34~2.00, P<0.000 1, partial remission(PR) RR=1.31, 95%CI=1.12~1.53, P=0.000 6, stable disease(SD) RR=0.35, 95%CI=0.26~0.48, P<0.000 1 and progressive disease(PD) RR=0.45, 95%CI=0.27~ 0.74, P<0.000 1. While it increased the risk of fever and skin reaction, and there was no significant difference in chest pain incidence. CONCLUSION Additional PAI increases the incidence of fever and skin reaction, while there are no severe events existed. Meanwhile, it also can to some extend improve relevant clinical index.