Systematic Review of the Therapeutic Efficacy of Kudiezi Injection on the Adjunctive Treatment of Diabetic Nephropathy

OBJECTIVE To evaluate therapeutic efficacy of kudiezi injection on the adjunctive treatment of diabetic nephropathy. METHODS Retrieved from PubMed, CNKI, VIP, CBM and Wangfang databas, randomized controlled trials(RCT) about kudiezi injection in the adjunctive treatment of diabetic nephropathy were included from January 1990 to july 2014 and comprehensively evaluated. The homogeneity test and combined test were performed by Rev Man 5.2 software. RESULTS Ten RCTs were included, invovling 1 138 patients. Meta-analysis showed that kudiezi injection could significantly decrease the value of urinary albumin excretion rate (UAER)SMD=-1.49, 95%CI(-1.97, -1.01), P<0.01 and serum creatinineSMD=-0.59, 95%CI(-0.80, -0.38), P<0.01, so could significantly improve the rate of clinical efficiencyRR=6.34, 95%CI(4.27, 9.41), P<0.01, but could not decrease the value of blood glucoseSMD=-0.18, 95%CI(-0.44, -0.08), P>0.01. CONCLUSION Kudiezi injection has clinical curative effect on the adjunctive treatment of diabetic nephropathy.