Comparison of Different Doses of Intranasal Dexmedetomidine Application Before General Anesthesia Induction

OBJECTIVE To investigate the right dose of intranasal dexmedetomidine(DEX) application before anesthesia induction. METHODS All of 120 cases received surgery were randomly divided into four groups, including intranasal 0.9% sodium chloride, 0.5, 1.5, 2.5 μg·kg^-1 DEX groups. Endotracheal intubation and mechanical ventilation were done after anesthesia induction. The patients were sent to the recovery room after operation. Monitoring indicators including intranasal DEX sedation score 30 min later, hemodynamic changes after intubation (mean arterial pressure and heart rate) and the incidence of adverse events, extubation time, pain score and cases of agitation. RESULTS OAA/S score in DEX 0.5, 1.5 and 2.5 μg·kg^-1 group decreased 30 min after intranasal(P<0.05); HR and MAP in DEX 1.5 μg·kg^-1 group decreased 30 min after intranasal(P<0.05); HR and MAP in the control group and DEX 0.5 μg·kg^-1 group increased at immediate intubation, while decreased in DEX 2.5 μg·kg^-1 group(P<0.05). The cases of tachycardia and hypertension in DEX 1.5 μg·kg^-1 group and DEX 2.5 μg·kg^-1 group decreased(P<0.05). The cases of bradycardia and hypotension increased increased in DEX 2.5 μg·kg^-1 group(P<0.05). Extubation time in DEX 2.5 μg·kg^-1 group was extended(P<0.05). The VAS score after extubation and the cases of agitation in DEX 1.5 and 2.5 μg·kg^-1 group were decreased(P<0.05). CONCLUSION Endotracheal intubation can be well done with intranasal DEX 1.5 μg·kg^-1 30 min before anesthesia induction, at the same time all kinds of adverse reactions were reduced.