Intravenous Butorphanol-Etomidate Pretreatment Reduces Fentanyl-induced Cough

OBJECTIVE To observe the effect of intravenous Butorphanol-etomidate pretreatment on the rate of fentanyl-induced cough(FIC). METHODS Totally 200 American Society of Anesthesiologists scheduled for elective surgery, were randomly assigned to receive intravenous butorphanol 15 μg·kg^-1 and etomidate 0.2 mg·kg^-1(experimental group) or normal saline 0.15 mL·kg^-1 and Intralipid 0.2 mL·kg^-1(normal control group) 1 minutes prior to the administration of Fentanyl 4 μg·kg^-1 in a randomized and double-blind fashion. Any episode of cough was classified as difesent degree. Timing and severity of cough were recorded and monitored the vital signs and discomforts. RESULTS The incidence of cough was 2.0% in experimental group and 36% in normal control group(P<0.05).The incidence of moderate and severe cough was significantly higher in the normal control group(55.6%, 20/36) than in experimental group(0%)(P<0.05).There was no significant difference between these two groups in the timing of cough. CONCLUSION Butorphanol-etomidate pretreatment can effectively reduce the incidence and severity of FIC.