Study on the Stability of Vidarabine Monophosphate in Pediatric Electrolyte Supplements Injection

OBJECTIVE To investigate the stability of vidarabine monophosphate for injection in Pediatric Electrolyte Supplements Injection. METHODS The relative content of vidarabine monophosphate in Pediatric Electrolyte Supplements injection was determined by HPLC in 24ｈat 5, 25, 35 ℃ under dark and light, and the changes in appearance, pH value and insoluble particles were observed. RESULTS There were no significant changes in appearance and pH value at 5, 25, 35 ℃ under dark, insoluble particles were in line with Chinese Pharmacopoeia(2010 edition), and the relative content of vidarabine monophosphate were above 99%(compared with 0 h) in 24 h. In the light conditions, as the temperature raised, the extension of storage time, the content of vidarabine monophosphate had declined, while pH value and insoluble particles did not change. CONCLUSION Vidarabine monophosphate for injection compatibled with pediatric electrolyte are stable under dark conditions in 24 h. The light is the main influential factor of the stability.